Vertex Pharmaceuticals

Vertex Pharmaceuticals is a global biotechnology company focused on discovering, developing, and commercializing transformative medicines for serious diseases. Through strategic partnerships and investments, Vertex has been a pioneer in gene editing therapeutics, including their landmark collaboration with CRISPR Therapeutics that led to the first FDA-approved CRISPR-based therapy.

Location
Boston, Massachusetts, USA
Founded
1989
AUM
N/A (strategic investments)
Investment Range
$50M - $500M (partnerships)
Portfolio Companies
1
Focus
cvc
Fund Stages
series-a, series-b, series-c, growth

Investment Thesis

Vertex pursues strategic investments and partnerships that complement and expand their pipeline across gene editing, cell therapy, and novel therapeutic modalities. They focus on cutting-edge science that can transform treatment paradigms for serious diseases, particularly in areas where they have deep expertise like genetic diseases and cystic fibrosis.

Team

Executive Leadership

  • Reshma Kewalramani, MD - CEO & President
  • Stuart Arbuckle - EVP & Chief Commercial Officer
  • David Altshuler, MD, PhD - EVP, Global Research & Chief Scientific Officer

Business Development

  • Jeffrey Leiden, MD, PhD - Executive Chairman (former CEO)
  • Corporate development team handles strategic investments

Focus Areas

  • Gene Editing (CRISPR/Cas9)
  • Gene Therapy
  • Cell Therapy
  • Cystic Fibrosis
  • Sickle Cell Disease & Beta-Thalassemia
  • Type 1 Diabetes
  • Pain
  • Kidney Disease

Strategic Partnerships & Investments

  • CRISPR Therapeutics - Strategic partner and investor, co-developed Casgevy (first FDA-approved CRISPR therapy, December 2023)
  • Arbor Biotechnologies - Gene editing partnership
  • Mammoth Biosciences - Next-gen gene editing
  • Entrada Therapeutics - Intracellular biologics
  • ViaCyte - Cell therapy for diabetes (acquired 2022)

Notable Exits/Milestones

  • Casgevy - First FDA-approved CRISPR gene-editing therapy (December 2023)
  • Trikafta - Transformative cystic fibrosis treatment ($8B+ annual revenue)
  • Multiple strategic acquisitions including Semma Therapeutics, Exonics Therapeutics

Sources

Portfolio Companies

NameLocationFoundedCategories
CRISPR TherapeuticsZug, Switzerland & Boston, Massachusetts, USA2013
therapeuticsbiotech+4