Apple Tree Partners
Life sciences venture capital firm focused on building breakthrough biotechnology companies. Known for deep scientific expertise and company-building approach, with strong track record in therapeutics and platform technologies.
Location
New York, USA
Founded
2000
AUM
$1.5B+
Investment Range
$10M - $75M
Portfolio Companies
23
Focus
biotech-focused
Fund Stages
series-a, series-b, series-c, growth
Investment Thesis
Apple Tree Partners invests in biotechnology companies with transformative therapeutic potential, focusing on novel drug targets and platform technologies. They take a hands-on approach to company building, leveraging their team's deep experience in drug development and biotech operations.
Team
Partners / Managing Directors (Health & Bio Focus)
- Seth Harrison, MD - Managing Partner
- David Kabakoff, PhD - Partner
- Vikram Sinha, PhD - Partner
Other Key Team Members
- Niall O'Donnell, PhD - Partner
Focus Areas
- Therapeutics
- Oncology
- Immunology
- Rare Diseases
- Platform Technologies
- Drug Discovery
- Gene Therapy
Notable Exits
- Acceleron Pharma - Acquired (2021, by Merck for $11.5B)
- Receptos - Acquired (2015, by Celgene for $7.2B)
- Tesaro - Acquired (2019, by GSK for $5.1B)
- Dermira - Acquired (2020, by Eli Lilly for $1.1B)
Sources
Portfolio Companies
| Name | Location | Founded | Categories |
|---|---|---|---|
| Aethon Therapeutics | - | - | - |
| Aileron Therapeutics | - | - | - |
| Akero Therapeutics | - | - | - |
| Apertor Pharmaceutical | - | - | pharmatherapeutics |
| Ascidian Therapeutics | Boston, Massachusetts, USA | 2020 | biotechRNA-editing+3 |
| Aulos Biosciences | Waltham, Massachusetts, USA | 2019 | biotechimmunotherapy+3 |
| Chinook Therapeutics | Seattle, Washington & Vancouver, British Columbia | 2019 | biotechnephrology+3 |
| Corvidia Therapeutics | Waltham, Massachusetts, USA | 2015 | biotechcardiovascular+3 |
| Deep Apple Therapeutics | - | - | aidrug-discovery+2 |
| Evercrisp Biosciences | - | - | biotechgene-therapy+1 |
| Galvanize Therapeutics | Redwood City, California, USA | 2017 | medical-devicesoncology+2 |
| Gloucester Pharmaceuticals | Cambridge, Massachusetts, USA | 2003 | biotechoncology+2 |
| Initial Therapeutics | Cambridge, Massachusetts, USA | 2021 | biotechdrug-discovery+2 |
| Marengo Therapeutics | Cambridge, Massachusetts, USA | 2018 | biotechimmunotherapy+3 |
| Marlins Pike Therapeutics | - | - | biotechtherapeutics+1 |
| Nereid Therapeutics | - | - | biotechtherapeutics+1 |
| Nine Square Therapeutics | San Francisco, California, USA | 2021 | biotechtherapeutics+2 |
| Red Queen Therapeutics | Boston, Massachusetts, USA | - | biotechoncology+2 |
| Replicate Biosciences | San Diego, California, USA | 2020 | biotechrna-therapeutics+3 |
| SGX Pharmaceuticals | San Diego, California, USA | 2002 | biotechdrug-discovery+2 |
| Stoke Therapeutics | Bedford, Massachusetts, USA | 2014 | biotechtherapeutics+3 |
| Tokai Pharmaceuticals | Cambridge, Massachusetts, USA | 2004 | biotechoncology+2 |
| Tucker Medical | United States | - | medical-deviceshealthcare |